Kidney Transplant Research Today is a free monthly online journal that collates and summarizes the latest research about Kidney Transplant, including details on risks, prognosis, procedure, surgery, organ donation.

Acne in recipients of renal transplantation treated with sirolimus: clinical, microbiologic, histologic, therapeutic, and pathogenic aspects.

Mahé E, Morelon E, Lechaton S, Drappier JC, de Prost Y, Kreis H, Bodemer C

Department of Dermatology, Bichat-Claude Bernard University Hospital, Paris, France. emmanuel.mahe@apr.aphp.fr

We evaluated the clinical characteristics of sirolimus-induced acne in 80 recipients of renal transplantation. It developed in 36 of 48 (75%) men and 2 of 32 (6%) women. Lesion locations and clinical, bacteriologic, and histologic features differentiated sirolimus-induced acne from acne vulgaris, but therapeutic management was similar. The main limitation for this study was the absence of a control group without sirolimus. Epidermal growth factor inhibition by sirolimus is a plausible explanation for this acne.

Published 19 June 2006 in J Am Acad Dermatol, 55(1): 139-42.
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