Kidney Transplant Research Today is a free monthly online journal that collates and summarizes the latest research about Kidney Transplant, including details on risks, prognosis, procedure, surgery, organ donation.

Chronic rejection: an enduring enigma of transplantation biology.

Vanikar AV, Trivedi HL

Department of Pathology, Laboratory Medicine, Transfusion Services and Immunohematology, Institute of Transplantation Sciences, Ahmedabad, Gujarat, India.

Renal transplantation has achieved reasonably good success over the years in controlling acute rejection episodes; however, the immunology of chronic rejection is still not well understood. The problem haunts transplanters across the globe. We describe the presentation, brief immunopathological events, and recent advances suggested by pathologists to define chronic rejection and differentiate it from chronic allograft nephropathy. Our experience using tolerance induction is briefly mentioned including a reduced incidence of acute rejection episodes, chronic rejection events, or calcineurin inhibitor toxicity using lower drug levels.

Published 20 April 2007 in Transplant Proc, 39(3): 773-8.
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